Basic Science Pathway
Clinical Research Pathway
Critical Care
Cross-Disciplinary Pathway
Neonatology
Neurology
Scholarly Sessions
Trainee Pathway
Lina Chalak, MD MSCS
Professor
pediatrics
UT Southwestern.edu
DALLAS, Texas, United States
Hypoxic-ischemic encephalopathy (HIE) presents with a neonatal encephalopathy (NE) where the mild spectrum is difficult to classify immediately after birth. For decades trials have focused exclusively on infants with moderate-severe HIE. Twenty years after those trials the fundamental question of how best to manage mild HIE remains unanswered.
This session led by an international expert panel will summarize the biological plausibility and evidence that neonates with mild HIE are at significant risk for adverse long term outcomes and the role of EEG, amplitude EEG and parenteral involvement to guide decision making in the first 6 hours critical window for decision. We discuss the loss of clinical equipoise regarding treatment in mild HIE and we review the underlying legal and ethical implications. The goal of this session is to advance our understanding of the evidence to guide a standardized approach and development of future trials. Dr Chalak and Dr Boylan will chair this international session, Dr Gun will present the evidence from animal studies, Dr Murray will summarize the importance of long term follow up, Dr Thayyil will present COMET II trial updates, Dr Chalak will discuss early physiological biomarkers and role of parents in alternate study designs, and Dr Oei will discuss the practical and legal ramifications.
The panel of speakers will host 15 minutes open debate for questions and answers.
Speaker: Lina Chalak, MD MSCS – UT Southwestern MC
Speaker: Alistair J. Gunn, MBChB, PhD, FRACP – University of Auckland
Speaker: Deirdre M. Murray, MB BAO BcH FRCPI FPAEDPhD – University College Cork
Speaker: Geraldine B. Boylan, PhD – University College Cork
Speaker: Sudhin Thayyil, MD, PhD – Imperial College London
Speaker: JULEE OEI, MBBS FRACP MD – ROYAL HOSPITAL FOR WOMEN
Speaker: Lina Chalak, MD MSCS – UT Southwestern MC
Speaker: Annie Janvier, MD, PhD – University of Montreal, CHU Sainte-Justine