3615 - TMI about TMA & complement dysregulation: clarifying updates for diagnosis and treatment

Monday, April 25, 2022

1:00 PM – 2:30 PM US MT

Location: Convention Center: 708/710/712

CE: Live CME: 1.5

Selected By: ASPN
Course Number: 3615

Chair(s)

AB

Abbie Bauer, MD, MS

Assistant Professor, Pediatric Nephrology
Doernbecher Children's Hospital at Oregon Health & Science University
PORTLAND, Oregon, United States
BD

Bradley Dixon, MD

Associate Professor of Pediatrics and Medicine
Pediatrics
University of Colorado School of Medicine
Aurora, Colorado, United States

Participants should be aware of the following financial/non-financial relationships:

Abbie R. Bauer, MD, MS: I do not have any relevant financial / non-financial relationships with any proprietary interests.

Bradley P. Dixon, MD FASN: ● Achillion Pharmaceuticals (Ended In the Past 24 Months) (Products/Services: Research Support including clinical trials & the principal or named investigator)
● Alexion Pharmaceuticals (Currently Ongoing) (Products/Services: Research Support including clinical trials & the principal or named investigator, Consultant)
● Apellis Pharmaceuticals (Currently Ongoing) (Products/Services: Research Support including clinical trials & the principal or named investigator, Consultant)

The goal of this session will be to review the clinical manifestations of complement dysregulation in pediatric kidney disease focused on atypical hemolytic syndrome, C3 glomerulopathy, and post-bone marrow transplant thrombotic microangiopathy. This session will focus on work up/diagnosis, pathological mechanisms with a focus on potential therapeutic targets, and current and emerging treatment options.

Presentations:

1:00 PM – 1:20 PM US MT

Atypical hemolytic syndrome: Pathophysiology and diagnostic update
Speaker: Stefanie W. Benoit, MD, MPH (she/her/hers) – Cincinnati Children's Hospital Medical Center
1:20 PM – 1:40 PM US MT

Atypical hemolytic syndrome and complement blockade
Speaker: Larry Greenbaum, MD, PhD (he/him/his) – Emory University School of Medicine
1:40 PM – 2:00 PM US MT

C3 glomerulopathy: Pathophysiology and advances in diagnosis & treatment
Speaker: Bradley P. Dixon, MD – University of Colorado School of Medicine
2:00 PM – 2:20 PM US MT

Post-bone marrow transplant thrombotic microangiopathy
Speaker: Chia Wei Teoh, MB BCh BAO, MRCPI, MSc – The Hospital for Sick Children