Adolescent Medicine
Developmental and Behavioral Pediatrics
Gastroenterology/Hepatology
General Pediatrics
Genomics/Epigenomics
Hospital Medicine
Mental Health
Pharmacology and Therapeutics
Scholarly Sessions
Highlighted Theme: Managing the Pediatric Mental Health Crisis
Sonya Tang Girdwood, MD, PhD (she/her/hers)
Assistant Professor of Pediatrics
Pediatrics
Cincinnati Children' Hospital Medical Center
Cincinnati, Ohio, United States
Tina Cheng, MD, MPH
Chair of Pediatrics, CMO, Director of the Cincinnati Children's Research Foundation
Cincinnati Children's Hospital, University of Cincinnati
Cincinnati, Ohio, United States
Pharmacogenetics is an important component of precision medicine, and the evidence for incorporating pharmacogenetics into clinical practice to improve outcomes in pediatrics is rapidly emerging. However, many pediatricians, whether generalists or subspecialists, lack formal training in incorporating pharmacogenetic test results into clinical practice. In this hot topic symposium, we will introduce participants to key terms used in pharmacogenetics literature and provide pharmacogenetics resources that are accessible to pediatricians. Following the introduction, four talks (15 minutes each) will provide a practical summary of the pharmacogenetics evidence and implications for clinical practice in different clinical areas within pediatrics. First, we will discuss one of the sentinel discoveries in the field of pharmacogenetics--the differential activation of codeine to morphine as a consequence of different CYP2D6 alleles, and how this pharmacogenetic discovery led to FDA label changes for codeine. We will expand this discussion to the pharmacogenetics of other opioids and NSAIDs used for pain control. Second, we will review the available pharmacogenetic evidence available for drugs relevant to the treatment of gastrointestinal disorders, including proton pump inhibitors and ondansetron, both prescribed frequently by general pediatricians and subspecialists for inpatient and outpatient use. Lastly, with the growing mental health crisis among children and adolescents, our final two presentations will focus on the relevance of pharmacogenetics to psychotropic medications for commonly encountered mental health disorders in pediatrics, including ADHD, anxiety and depression. The remaining 20 minutes of the special session will be a Q&A session, moderated by a general pediatrician and pediatric hospitalist.
Speaker: Sonya Tang Girdwood, MD, PhD – Cincinnati Children's Hospital Medical Center
Speaker: Tamorah Lewis, MD, PhD – University of Toronto School of Medicine
Speaker: Sara Van Driest, MD, PhD – Vanderbilt University Medical Center
Speaker: Laura Ramsey, PhD – Cincinnati Children's Hospital Medical Center
Speaker: Valentina Shakhnovich, MD – UMKC School of Medicine; Children's Mercy Kansas City