Academic and Research Skills
Basic Science Pathway
Developmental Biology
Neonatology
Neurology
Pulmonology
Well Newborn
Vineet Bhandari, MD, DM (he/him/his)
Professor and Division Head
Pediatrics
The Children's Regional Hospital at Cooper
Camden, New Jersey, United States
Sule Cataltepe, MD (she/her/hers)
Neonatologist
Brigham and Women's Hospital
Boston, Massachusetts, United States
Macroautophagy (referred to as autophagy hereafter) is a highly regulated and conserved intracellular pathway for lysosomal degradation that controls cellular bioenergetics and cytoplasmic quality. Autophagy plays an essential role in maintaining homeostasis and normal development, whereas dysregulated autophagy has been implicated in various pathologies as a cause of excessive inflammatory signaling and/or cell death. This session will bring together a panel of physicians and scientists to discuss the role of autophagy in normal lung development as well as in major morbidities that affect preterm and term infants, such as bronchopulmonary dysplasia, necrotizing enterocolitis, sepsis, and hypoxic-ischemic encephalopathy. Each speaker will present their own research data from in vitro and in vivo models and clinical specimens, review the current literature, and discuss potential preventive and therapeutic strategies targeting or augmenting autophagy during normal development and disease. Since the proposed talks will address the potential role of autophagy in pathologies that affect different organ systems, it will be of high relevance to clinicians and scientists with a wide range of research interests in developmental biology and neonatology. Furthermore, it is anticipated to serve as a catalyst to foster new collaborations and ideas to harness the therapeutic potential of autophagy as a master regulator of neonatal health and disease.
Speaker: Vineet Bhandari, MD, DM – The Children's Regional Hospital at Cooper
Speaker: Martin Post, PhD – Hospital for Sick Children
Speaker: Sule Cataltepe, MD – Brigham and Women's Hospital/Harvard Medical School
Speaker: Sailaja Ghanta, MD – Brigham and Women's Hospital
Speaker: David Hackam, MD, PhD – Johns Hopkins Children's Center
Speaker: Henrik Hagberg, PhD, MD – Clinical Sciences